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Dr. Li-Huei Tsai was born in Taipei, Taiwan. In 1986, she started her Ph.D. at the University of Texas Southwestern. Under the direction of Bradford Ozanne, she graduated in 1990 and joined Ed Harlow's laboratory at Cold Spring Harbor Laboratory and Massachusetts General Hospital for postdoctoral training. She was appointed Assistant Professor of Pathology at Harvard Medical School in 1994, elected Investigator of Howard Hughes Medical Institute in 1997, and promoted to Professor of Pathology in 2002. In 2006, she relocated her lab to MIT and became the Picower Professor of Neuroscience in the Picower Institute for Learning and Memory. She began directing the Neurobiology Program at the Stanley Center for Psychiatric Research in 2007.
A major research interest of the Tsai lab understanding neurodegenerative diseases associated with cognitive decline such as Alzheimer’s disease. Her findings have led to the hypothesis that deregulation of Cdk5, through conversion of p35 to p25, plays an important role in the pathogenesis of Alzheimer’s. Recently, she found that chromatin remodeling via increased histone acetylation is beneficial for learning impairment and memory loss caused by severe neurodegenreation in the inducible p25 mouse model. Li-Huei Tsai is on editorial boards for Neuron and NeuroSignals, serves as the reviewing editor for the Journal of Neuroscience, has been awarded the Young Investigator Award from Metropolitan Life Foundation, the Outstanding Contributor Award from the Alzheimer Research Forum. She sits on the scientific advisory boards and committees for NINDS, Alzheimer Research Forum , Hotchkiss Brain Institute at the University of Calgary, among other organizations.
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